Plectin is a 500kDa cytolinker protein found in the cytoplasm of mammalian cells. It acts as a scaffold between microfilaments, microtubules and intermediate filaments.
Plectin exists in cells as several alternatively-spliced isoforms. The structure of plectin is thought to be a dimer consisting of a central coiled coil of alpha helices connecting two large globular domains (one at each terminus). These globular domains are responsible for connecting plectin to its various cytoskeletal targets.
Although normally found in the cytoplasm, plectin is expressed on the cell membrane of multiple cancer cells and can therefore be targeted.