ZB131

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ZB131 is a proprietary humanized monoclonal antibody against cell surface plectin (CSP) a cancer target identified through Zielfind™. CSP is highly expressed on the plasma membrane of multiple types of cancer cells including, ovarian, pancreatic, lung and colorectal. Multiple publications on CSP and cancer can be found here.

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Compelling Profile

Extensive pre-clinical laboratory and animal research has demonstrated that ZB131 :

- Binds to CSP with high affinity, inducing growth arrest and necrosis of CSP-positive tumor cells

- Inhibits cancer cell migration, reducing metastatic potential

- Induces a striking three-fold increase in tumor-infiltrating activating T-cells

- Causes complete tumor regression and protection from tumor re-challenge in a syngeneic immunocompetent mouse model

Potentially Superior to Current Immuno-Oncology Therapies

- Immune activation exceeding checkpoint inhibitors like ipilumumab and nivolumab

- Greater direct tumor cell killing than trastuzumab and cetuximab

Minimal Risks 

ZB131 is primed for investment to enable rapid clinical development across multiple orphan and major cancer indications.

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Safe

– ZB131 expercted to be well-tolerated; no normal tissue expression / no safety findings in rodents (ZB131 binds to murine CSP/Plectin)

Efficacious

– ZB131 monotherapy shows greater efficacy in preclinical models than other approved functional antibodies and IO agents

Powerful

– ZB131 demonstrates synergistic activity with SOC chemotherapy providing an opportunity for clinical outcomes and early line therapy options

Manufacturable

– Low ZB131 manufacturing risk with favorable developability assessement completed

Versatile

– Additional modalities targeting CSP are possible (ADC, bispecifics, targeted cell-based therapy, etc)